While an expensive proposition, it could most certainly replace the 5spd I suppose, without much modifications.
Replacing the CVT is another story though. The ECM, TCM and all their buddies will be expecting a CVT in there and will fault every Christmas light they can if the CVT got yanked out.
Perhaps the only issue with the SRT GetRag tranny being put in lieu of the 5spd would be adapting the mount or link up with the wheels but that shouldn't be anything insurmountable.